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The Pediatric Emergency Care Applied Research Network (PECARN) is a collaborative research network focused on improving the emergency medical care of children in the United States. PECARN was established in 2001 and is comprised of 18 participating pediatric emergency departments across the country. The network conducts multi-center research to address the most pressing clinical questions in pediatric emergency medicine, with the goal of improving the outcomes and quality of care for children. PECARN's research covers a wide range of topics, including traumatic brain injury, asthma, and infectious diseases, and its findings have influenced clinical practice guidelines and policies. By bringing together leading pediatric emergency care providers and researchers, PECARN plays a crucial role in advancing the field of pediatric emergency medicine.