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Charcot-Marie-Tooth (CMT) disease is a genetic neurological disorder that affects the peripheral nerves, leading to muscle weakness and atrophy, as well as sensory loss in the arms, legs, hands, and feet. It is one of the most common inherited neurological disorders, with symptoms typically appearing in adolescence or early adulthood. CMT is caused by mutations in various genes that play a role in the structure and function of peripheral nerves, leading to impaired nerve signals and muscle function. There is currently no cure for CMT, but treatment focuses on managing symptoms and improving quality of life through physical therapy, assistive devices, and, in some cases, surgery. Research into potential gene therapies and other interventions is ongoing.